Vast undertreatment of diabetes seen in global study

NEARLY half-a-billion people on the planet have diabetes but most of them aren’t getting the kind of care that could make their lives healthier, longer, and more productive, according to a new global study of data from people with the condition.

Many don’t even know they have the condition.

Only one in 10 people with diabetes, in the 55 low- and middle-income countries studied, receive the type of comprehensive care that’s been proven to reduce diabetes-related problems, according to the new findings published in The Lancet Healthy Longevity.

That comprehensive package of care — low-cost medicines to reduce blood sugar, blood pressure and cholesterol levels; and counselling on diet, exercise and weight — can help lower the health risks of under-treated diabetes. Those risks include future heart attacks, strokes, nerve damage, blindness, amputations, and other disabling or fatal conditions.

The study, led by physicians at the University of Michigan and Brigham and Women’s Hospital, along with a global team of partners, draws on data from standardised household studies to allow for apples-to-apples comparisons between countries and regions.

The authors analysed data from surveys, examinations and tests of more than 680,000 people between the ages of 25 and 64 worldwide, conducted in recent years. More than 37,000 of them had diabetes; more than half of them hadn’t been formally diagnosed yet, but had a key biomarker of elevated blood sugar.

The researchers have provided their findings to the World Health Organization, which is developing efforts to scale up delivery of evidence-based diabetes care globally as part of an initiative known as the Global Diabetes Compact. The forms of diabetes-related care used in the study are all included in the 2020 WHO Package of Essential Noncommunicable Disease Interventions.

“Diabetes continues to explode everywhere, in every country, and 80 per cent of people with it live in these low- and middle-income countries,” says Dr David Flood, lead author and a national clinician scholar at the University of Michigan Institute for Healthcare Policy and Innovation. “It confers a high risk of complications such as including heart attacks, blindness and strokes. We can prevent these complications with comprehensive diabetes treatment, and we need to make sure people around the world can access treatment.”

Dr Flood worked with senior author Dr Jennifer Manne-Goehler of Brigham and Women’s Hospital and the Medical Practice Evaluation Center at Massachusetts General Hospital to lead the analysis of detailed global data.


Key findings

In addition to the main finding that 90 per cent of the people with diabetes studied weren’t getting access to all six components of effective diabetes care, the study also found major gaps in specific care.

For instance, while about half of all people with diabetes were taking a drug to lower their blood sugar, and 41 per cent were taking a drug to lower their blood pressure, only 6.3 per cent were receiving cholesterol-lowering medications.

These findings show the need to scale up proven treatment, not only to lower glucose, but also to address cardiovascular disease risk factors such as hypertension and high cholesterol in people with diabetes.

Less than a third had access to counselling on diet and exercise, which can help guide people with diabetes to adopt habits that can control their health risks further.

Even when the authors focused on the people who had already received a formal diagnosis of diabetes, they found that 85 per cent were taking a medicine to lower blood sugar, 57 per cent were taking a blood pressure medication, but only nine per cent were taking something to control their cholesterol. Nearly 74 per cent had received diet-related counselling, and just under 66 per cent had received exercise and weight counselling.

Taken together, less than one in five people with previously diagnosed diabetes were getting the full package of evidence-based care.


Relationship to national income and personal characteristics

In general, the study found that people were less likely to get evidence-based diabetes care the lower the average income of the country and region they lived in. That’s based on a model that the authors created using economic and demographic data about the countries that were included in the study.

The nations in the Oceania region of the Pacific had the highest prevalence of diabetes — both diagnosed and undiagnosed — but the lowest rates of diabetes-related care.

But there were exceptions where low-income countries had higher-than-expected rates of good diabetes care, says Dr Flood, citing the example of Costa Rica. And in general, the Latin America and Caribbean region was second only to Oceania in diabetes prevalence, but had much higher levels of care.

Focusing on what countries with outsize achievements in diabetes care are doing well, could provide valuable insights for improving care elsewhere, the authors say. That even includes informing care in high-income countries like the United States, which does not consistently deliver evidence-based care to people with diabetes.

The study also shines a light on the variation between countries and regions in the percentage of cases of diabetes that have been diagnosed. Improved, reliable access to diabetes diagnostic technologies is important in leading more people to obtain preventative care and counselling.

Women, people with higher levels of education and higher personal wealth, and people who are older or had high body mass index were more likely to be receiving evidence-based diabetes care. Diabetes in people with “normal” BMI is not uncommon in low- and middle-income countries, suggesting there needs to be more focus on these individuals, the authors say.

The fact that diabetes-related medications are available at very low cost and that individuals can reduce their risk through lifestyle changes, mean that cost should not be a major barrier, says Flood. In fact, studies have shown the medications to be cost-effective, meaning that the cost of their early and consistent use is outweighed by the savings on other types of care later.


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